Mis-splicing drives loss of function of p53E224D point mutation.

Mis-splicing drives loss of function of p53E224D point mutation.

<h4>Background</h4>The tumor suppressor p53 (Trp53), also known as p53, is the most commonly mutated gene in cancer. Canonical p53 DNA damage response pathways are well characterized and classically thought to underlie the tumor suppressive effect of p53. Challenging this dogma, mouse mo...

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Main Authors: Ian C Lock, Nathan H Leisenring, Warren Floyd, Eric S Xu, Lixia Luo, Yan Ma, Erin C Mansell, Diana M Cardona, Chang-Lung Lee, David G Kirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318856
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https://doi.org/10.1371/journal.pone.0318856

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