Modified ZhuJing pill protects retinal pigment epithelium against oxidative stress-induced epithelial–mesenchymal transition through Nrf2-mediated Akt/GSK3β pathway

Modified ZhuJing pill protects retinal pigment epithelium against oxidative stress-induced epithelial–mesenchymal transition through Nrf2-mediated Akt/GSK3β pathway

BackgroundThe modified ZhuJing pill (mZJP) has been widely used in China as a classical prescription for treating retinal diseases for years. Our preliminary experiment showed that mZJP exerted an antioxidant effect in treating dry age-related macular degeneration (AMD). Nevertheless, the specific m...

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Bibliographic Details
Main Authors: Ning Yang, Caijian Xiong, Siqi Feng, Mengqi Gao, Siqi Zhou, Qinyi Hui, Xin Zhou, Qingzi Jin, Yan Shao, Xinrong Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
age-related macular degeneration
Nrf2 pathway
epithelial–mesenchymal transition
Akt/GSK3β pathway
modified ZhuJing pill
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545731/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1545731/full

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