Evaluating the representational power of pre-trained DNA language models for regulatory genomics

Abstract Background The emergence of genomic language models (gLMs) offers an unsupervised approach to learning a wide diversity of cis-regulatory patterns in the non-coding genome without requiring labels of functional activity generated by wet-lab experiments. Previous evaluations have shown that...

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Bibliographic Details
Main Authors: Ziqi Tang, Nirali Somia, Yiyang Yu, Peter K. Koo
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Genome Biology
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Online Access:https://doi.org/10.1186/s13059-025-03674-8
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