Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila.

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila.

O-GlcNAcylation is a reversible co-/post-translational modification involved in a multitude of cellular processes. The addition and removal of the O-GlcNAc modification is controlled by two conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase (OGA). Mutations in OGT have recently bee...

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Main Authors: Michaela Fenckova, Villo Muha, Daniel Mariappa, Marica Catinozzi, Ignacy Czajewski, Laura E R Blok, Andrew T Ferenbach, Erik Storkebaum, Annette Schenck, Daan M F van Aalten
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010159&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1010159&type=printable

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