Ameliorative Effect of Chitosan/<i>Spirulina platensis</i> Ethanolic Extract Nanoformulation against Cyclophosphamide-Induced Ovarian Toxicity: Role of PPAR-γ/Nrf-2/HO-1 and NF-<span style="font-variant: small-caps">k</span>B/TNF-α Signaling Pathways

Ameliorative Effect of Chitosan/<i>Spirulina platensis</i> Ethanolic Extract Nanoformulation against Cyclophosphamide-Induced Ovarian Toxicity: Role of PPAR-γ/Nrf-2/HO-1 and NF-<span style="font-variant: small-caps">k</span>B/TNF-α Signaling Pathways

Cyclophosphamide (CP) is an anticancer drug that causes infertility disorders. This study was designed to evaluate a nanoformulation of chitosan with an ethanolic extract from <i>Spirulina platensis</i> in terms of its protection against cyclophosphamide-induced ovarian toxicity. Nine gr...

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Bibliographic Details
Main Authors: May Almukainzi, Thanaa A. El-Masry, Hanaa A. Ibrahim, Hebatallah M. Saad, Enas I. El Zahaby, Asmaa Saleh, Maysa M. F. El-Nagar
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Marine Drugs
Subjects:
cyclophosphamide
chitosan/<i>Spirulina platensis</i>
ethanolic extract
ovarian toxicity
Nrf-2
Online Access:https://www.mdpi.com/1660-3397/22/9/395
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