Purinosomes as a therapeutic target in hepatocellular carcinoma: insights and opportunities

Abstract The formation of purinosomes, dynamic complexes involved in de novo purine biosynthesis, has been recognized as a critical process for cell growth. Although their upregulation in cancer cells suggests their potential as a therapeutic target, the specific role of purinosomes in hepatocellula...

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Bibliographic Details
Main Authors: Zhen Lin, Jia-Wei Long, Ming-chun Zhao, Pin Guo, Jin Wen, Guang-Liang Chen
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
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Online Access:https://doi.org/10.1007/s12672-025-02366-w
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