Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

Abstract Background Previous studies have reported several genetic loci associated with lung function. However, the mediating mechanism between these genetic loci and lung function phenotype is rarely explored. In this research, we used a cross-tissue multi-omics post-GWAS analysis to explain the as...

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Bibliographic Details
Main Authors: Shisheng Peng, Jinlong Fang, Weiliang Mo, Guodong Hu, Senquan Wu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Genomics
Subjects:
Lung function
DNA methylation
Gene expression
Cross-tissue targets
Multi-omics analysis
Online Access:https://doi.org/10.1186/s12864-025-11476-2
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https://doi.org/10.1186/s12864-025-11476-2

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