A Novel LC-MS/MS Method for the Measurement of Elexacaftor, Tezacaftor and Ivacaftor in Plasma, Dried Plasma Spot (DPS) and Whole Blood in Volumetric Absorptive Microsampling (VAMS) Devices

A Novel LC-MS/MS Method for the Measurement of Elexacaftor, Tezacaftor and Ivacaftor in Plasma, Dried Plasma Spot (DPS) and Whole Blood in Volumetric Absorptive Microsampling (VAMS) Devices

<b>Background:</b> The combination of ivacaftor, tezacaftor and elexacaftor (ETI) is approved for patients with cystic fibrosis (CF) aged two years and older and at least one F508del mutation in the CFTR gene. Variability in ETI treatment response has been repeatedly reported, and its re...

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Main Authors: Federica Pigliasco, Alessia Cafaro, Sebastiano Barco, Federico Cresta, Rosaria Casciaro, Nicoletta Pedemonte, Francesca Mattioli, Carlo Castellani, Giuliana Cangemi
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceutics
Subjects:
CFTR modulators
cystic fibrosis
liquid chromatograph–tandem mass spectrometry
microsampling
pediatric pharmacology
Online Access:https://www.mdpi.com/1999-4923/17/2/200
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