Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.

Loss of murine Gfi1 causes neutropenia and induces osteoporosis depending on the pathogen load and systemic inflammation.

Gfi1 is a key molecule in hematopoietic lineage development and mutations in GFI1 cause severe congenital neutropenia (SCN). Neutropenia is associated with low bone mass, but the underlying mechanisms are poorly characterized. Using Gfi1 knock-out mice (Gfi1-ko/ko) as SCN model, we studied the relat...

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Main Authors: Sven Geissler, Martin Textor, Sabine Stumpp, Sebastian Seitz, Anja Lekaj, Sabrina Brunk, Sabine Klaassen, Thorsten Schinke, Christoph Klein, Stefan Mundlos, Uwe Kornak, Jirko Kühnisch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198510/1/pone.0198510.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210222%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210222T092029Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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