Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

Efficiently targeting neuroblastoma with the combination of anti-ROR1 CAR NK cells and N-803 in vitro and in vivo in NB xenografts

The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor en...

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Main Authors: Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Timothy P. Cripe, Mitchell S. Cairo
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
neuroblastoma
chimerical antigen receptor
ROR1
expanded natural killer cells
targeted immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000626
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