The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology.

The balance between pro-inflammatory and regulatory immune responses in determining optimal T cell activation is vital for the successful resolution of microbial infections. This balance is maintained in part by the negative regulators of T cell activation, CTLA-4 and PD-1/PD-L, which dampen effecto...

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Main Authors: Julius Clemence R Hafalla, Carla Claser, Kevin N Couper, Georges Emile Grau, Laurent Renia, J Brian de Souza, Eleanor M Riley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002504&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002504&type=printable

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