Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study

Comparative effectiveness of epilepsy surgery versus additional anti-seizure medications for Lennox–Gastaut syndrome: study protocol for a multicenter, mixed-methods study

IntroductionLennox–Gastaut Syndrome (LGS) is a severe developmental epileptic encephalopathy without a known cure. Management of symptoms requires substantial care. Treatment options include anti-seizure medications, dietary therapy, and epilepsy surgery. Two main treatment pathways for patients wit...

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Main Authors: Sandi Lam, Marc Rosenman, Tracy Dixon-Salazar, Kelly G. Knupp, Liu Lin Thio, Taylor J. Abel, William P. Welch, Laurel Reed, Stephanie C. Randle, Rebecca Garcia-Sosa, Jason S. Hauptman, Carolyn C. Foster, Elizabeth R. Alpern, Lu Zhang, Nicole Villalba, Maura Carroll, Anup D. Patel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Neurology
Subjects:
Lennox–Gastaut syndrome
epilepsy
epilepsy surgery
anti-seizure medications
comparative effectiveness study
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1569551/full
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https://www.frontiersin.org/articles/10.3389/fneur.2025.1569551/full

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