Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Somatic gene delivery faithfully recapitulates a molecular spectrum of high-risk sarcomas

Abstract A major challenge hampering therapeutic advancements for high-risk sarcoma patients is the broad spectrum of molecularly distinct sarcoma types and the corresponding lack of suitable model systems. Here we describe the development of a genetically-controlled, yet versatile mouse modeling pl...

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Main Authors: Roland Imle, Daniel Blösel, Felix K. F. Kommoss, Sara Placke, Eric Stutheit-Zhao, Christina Blume, Dmitry Lupar, Lukas Schmitt, Claudia Winter, Lena Wagner, Malte von Eicke, Hannah Walzer, Julia Förderer, Stephanie Laier, Michael Hertwig, Heike Peterziel, Ina Oehme, Sophia Scheuerman, Christian M. Seitz, Florian H. Geyer, Florencia Cidre-Aranaz, Thomas G. P. Grünewald, Christian Vokuhl, Priya Chudasama, Claudia Scholl, Claudia Schmidt, Patrick Günther, Martin Sill, Kevin B. Jones, Stefan M. Pfister, Robert J. Autry, Ana Banito
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60519-5
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https://doi.org/10.1038/s41467-025-60519-5

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