Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise

Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise

Abstract Fecal microbiota transplantation (FMT) has shown efficacy for the treatment of ulcerative colitis but with variable response between patients and trials. The mechanisms underlying FMT’s therapeutic effects remains poorly understood but is generally assumed to involve engraftment of donor mi...

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Main Authors: Shahrokh Shekarriz, Jake C. Szamosi, Fiona J. Whelan, Jennifer T. Lau, Josie Libertucci, Laura Rossi, Michelle E. Fontes, Melanie Wolfe, Christine H. Lee, Paul Moayyedi, Michael G. Surette
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58673-x
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https://doi.org/10.1038/s41467-025-58673-x

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