Genomic alterations in normal breast tissues preceding breast cancer diagnosis

Genomic alterations in normal breast tissues preceding breast cancer diagnosis

Abstract Background Normal breast tissues adjacent to cancer often harbor many of the same genomic alterations as the cancer itself. However, it remains unclear whether histologically normal breast tissues carry genomic changes related to cancer development years before a cancer diagnosis. Methods W...

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Bibliographic Details
Main Authors: Jiawei Dai, Mariya Rozenblit, Xiaoyue Li, Naing Lin Shan, Yueyue Wang, Shrikant Mane, Michal Marczyk, Lajos Pusztai
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer precursors
Whole exome sequencing
Early tumorigenesis
Mutation signatures
Immune polymorphisms
Online Access:https://doi.org/10.1186/s13058-025-02018-5
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https://doi.org/10.1186/s13058-025-02018-5

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