New insights into the role of mitophagy related gene affecting the metastasis of osteosarcoma through scRNA-seq and CRISPR-Cas9 genome editing

Abstract Background Osteosarcoma (OSA), the most common primary bone malignancy, poses significant challenges due to its aggressive nature and propensity for metastasis, especially in adolescents. Mitophagy analysis can help identify new therapeutic targets and combined treatment strategies. Methods...

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Bibliographic Details
Main Authors: Sikuan Zheng, Mengliang Luo, Hong Huang, Xuanxuan Huang, Zhidong Peng, Shaowei Zheng, Jianye Tan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cell Communication and Signaling
Online Access:https://doi.org/10.1186/s12964-024-01989-w
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