Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing

Targeting Transcriptional Regulators Affecting Acarbose Biosynthesis in <i>Actinoplanes</i> sp. SE50/110 Using CRISPRi Silencing

Acarbose, a pseudo-tetrasaccharide produced by <i>Actinoplanes</i> sp. SE50/110, is an α-glucosidase inhibitor and is used as a medication to treat type 2 diabetes. While the biosynthesis of acarbose has been elucidated, little is known about its regulation. Gene silencing using CRISPRi...

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Bibliographic Details
Main Authors: Saskia Dymek, Lucas Jacob, Alfred Pühler, Jörn Kalinowski
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Microorganisms
Subjects:
<i>Actinoplanes</i>
acarbose
CRISPR interference
CRISPRi
library
transcriptional regulators
Online Access:https://www.mdpi.com/2076-2607/13/1/1
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