Analytical validation of total mucin concentration assay using SEC MALLS dRI for diagnosing and monitoring mucoobstructive lung diseases

Analytical validation of total mucin concentration assay using SEC MALLS dRI for diagnosing and monitoring mucoobstructive lung diseases

Abstract Mucins play a pivotal role in the pathophysiology of mucoobstructive lung diseases. Accurate quantification of total mucin concentrations in clinical sputum samples is critical for developing objective biomarkers for diagnosis, prognosis, and therapeutic monitoring. By using sputum samples...

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Bibliographic Details
Main Authors: Esin Ozkan, Stephanie Sue Livengood, Amina Ahmad Ford, Jade Kathryn Macdonald, Sophia Samir, Ian William Klevans, Mehmet Kesimer
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Mucins
Mucus
Sputum
Measurement method
Analytical validation
Online Access:https://doi.org/10.1038/s41598-025-97808-4
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https://doi.org/10.1038/s41598-025-97808-4

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