Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study
Objectives Gallstone disease (GSD) can be caused by various health and clinical factors such as obesity, dyslipidaemia and an unhealthy diet, all of which are associated with higher high-sensitivity C reactive protein (hs-CRP) concentrations. Whether hs-CRP represents an independent risk factor for...
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BMJ Publishing Group
2020-09-01
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| author | Tong Liu Wenqiang Li Sarah Tan Siyin Nan Yao Ning Duan Guoshuai Xu Jun Qu Siqing Liu |
| author_facet | Tong Liu Wenqiang Li Sarah Tan Siyin Nan Yao Ning Duan Guoshuai Xu Jun Qu Siqing Liu |
| author_sort | Tong Liu |
| collection | DOAJ |
| description | Objectives Gallstone disease (GSD) can be caused by various health and clinical factors such as obesity, dyslipidaemia and an unhealthy diet, all of which are associated with higher high-sensitivity C reactive protein (hs-CRP) concentrations. Whether hs-CRP represents an independent risk factor for GSD is still unclear. We prospectively investigated hs-CRP in relation to the occurrence of GSD based on the Kailuan study.Study design Prospective cohort study.Setting The Kailuan cohort study was conducted in Tangshan City in northern China.Participants 95 319 participants who were free from GSD were recruited in this study. Epidemiological data, anthropometric parameters and biochemical data of participants were collected.Primary and secondary outcome measures Cox proportional hazards regression models were used to evaluate the association between hs-CRP concentrations and the risk of GSD after adjustments for potential confounders.Results During the mean 7.58 years of follow-up among 95 319 participants, 4205 participants were identified as newly diagnosed with GSD or having undergone cholecystectomy for cholelithiasis. Compared with the hs-CRP<1 mg/L group, elevated hs-CRP concentrations were significantly associated with higher risk of GSD with the corresponding HR of 1.11 (95% CI 1.03 to 1.19), 1.12 (95% CI 1.04 to 1.22) in the 1≤hs-CRP≤3 mg/L and hs-CRP>3 mg/L group, respectively. The multivariate model which included hs-CRP not only had a better line of fitness but also had better predictive values to help identify new cases of GSD during follow-up.Conclusion Elevated hs-CRP concentration is an independent risk factor for new-onset GSD among the Chinese population.Trial registration number ChiCTR-TNC-11001489. |
| format | Article |
| id | doaj-art-25eda360a05b452083ef2c1c43f39366 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-25eda360a05b452083ef2c1c43f393662025-01-09T06:10:09ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-035880Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort studyTong Liu0Wenqiang Li1Sarah Tan Siyin2Nan Yao3Ning Duan4Guoshuai Xu5Jun Qu6Siqing Liu7Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin, China1 Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaDepartment of General Surgery, Beijing Children’s Hospital, National Center for Children’s Health, Beijing, ChinaDepartment of General Surgery, Aerospace Center Hospital, Haidian, Beijing, ChinaDepartment of General Surgery, Aerospace Center Hospital, Haidian, Beijing, ChinaDepartment of General Surgery, Aerospace Central Hospital, Beijing, ChinaDepartment of General Surgery, Aerospace Center Hospital, Haidian, Beijing, ChinaDepartment of Hepatological Surgery, Kailuan General Hospital, Tangshan, ChinaObjectives Gallstone disease (GSD) can be caused by various health and clinical factors such as obesity, dyslipidaemia and an unhealthy diet, all of which are associated with higher high-sensitivity C reactive protein (hs-CRP) concentrations. Whether hs-CRP represents an independent risk factor for GSD is still unclear. We prospectively investigated hs-CRP in relation to the occurrence of GSD based on the Kailuan study.Study design Prospective cohort study.Setting The Kailuan cohort study was conducted in Tangshan City in northern China.Participants 95 319 participants who were free from GSD were recruited in this study. Epidemiological data, anthropometric parameters and biochemical data of participants were collected.Primary and secondary outcome measures Cox proportional hazards regression models were used to evaluate the association between hs-CRP concentrations and the risk of GSD after adjustments for potential confounders.Results During the mean 7.58 years of follow-up among 95 319 participants, 4205 participants were identified as newly diagnosed with GSD or having undergone cholecystectomy for cholelithiasis. Compared with the hs-CRP<1 mg/L group, elevated hs-CRP concentrations were significantly associated with higher risk of GSD with the corresponding HR of 1.11 (95% CI 1.03 to 1.19), 1.12 (95% CI 1.04 to 1.22) in the 1≤hs-CRP≤3 mg/L and hs-CRP>3 mg/L group, respectively. The multivariate model which included hs-CRP not only had a better line of fitness but also had better predictive values to help identify new cases of GSD during follow-up.Conclusion Elevated hs-CRP concentration is an independent risk factor for new-onset GSD among the Chinese population.Trial registration number ChiCTR-TNC-11001489.https://bmjopen.bmj.com/content/10/9/e035880.full |
| spellingShingle | Tong Liu Wenqiang Li Sarah Tan Siyin Nan Yao Ning Duan Guoshuai Xu Jun Qu Siqing Liu Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study BMJ Open |
| title | Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study |
| title_full | Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study |
| title_fullStr | Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study |
| title_full_unstemmed | Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study |
| title_short | Relationship between high-sensitivity C reactive protein and the risk of gallstone disease: results from the Kailuan cohort study |
| title_sort | relationship between high sensitivity c reactive protein and the risk of gallstone disease results from the kailuan cohort study |
| url | https://bmjopen.bmj.com/content/10/9/e035880.full |
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