Effect of Selective Cysteinyl Leukotriene Receptor Antagonists on Airway Inflammation and Matrix Metalloproteinase Expression in a Mouse Asthma Model

Effect of Selective Cysteinyl Leukotriene Receptor Antagonists on Airway Inflammation and Matrix Metalloproteinase Expression in a Mouse Asthma Model

Cysteinyl leukotrienes (CysLTs) play a major role in the pathogenic changes of airway inflammation in asthma treatment. The matrix metalloproteinase (MMP) family, especially MMP-9 and MMP-2 levels, can reflect the status of airway remodeling. This study was undertaken to determine the role of a spec...

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Bibliographic Details
Main Authors: Chia-Hsiu Hsu, Chun-Ming Hu, Ko-Hsiu Lu, Shun-Fa Yang, Chung-Hung Tsai, Chun-Liang Ko, Hai-Lun Sun, Ko-Huang Lue
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Pediatrics and Neonatology
Subjects:
bronchoalveolar lavage fluid
cysteinyl leukotriene receptor
eosinophils
matrix metalloproteinase- 2, 9
mucus
subepithelial fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1875957212000691
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