ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology

ATP11B Modulates Microglial Lipid Metabolism and Alleviates Alzheimer's Disease Pathology

ABSTRACT Abnormal lipid metabolism in microglia leads to the formation of pathological lipid droplets (LDs), a phenomenon also observed in neurodegenerative diseases such as Alzheimer's disease (AD). The abnormal accumulation of LDs disrupts normal cellular function and exacerbates the patholog...

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Main Authors: Yuchen Zhang, Shibo Zhang, Xuyu Zhao, Peiru Wu, Yiwei Ying, Lingling Wu, Junyi Zhuang, Zixin Chen, Yufan Chao, Xin Dong, Robert Chunhua Zhao, Jiao Wang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:MedComm
Subjects:
Alzheimer's disease
ATP11B
lipid droplets
lipid metabolism
microglia
Online Access:https://doi.org/10.1002/mco2.70139
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https://doi.org/10.1002/mco2.70139

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