Placental histology, perioperative brain development, and neurodevelopmental outcome at 1 year of age in patients undergoing neonatal cardiac surgery—is there an association?

BackgroundPatients with congenital heart disease (CHD) who are operated on after birth are at risk for neurodevelopmental (ND) impairment. Before birth, altered fetal hemodynamics due to the CHD may lead to reduced cerebral perfusion and oxygen supply. The placenta as a critical organ may enhance th...

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Main Authors: Céline Steger, Alexander Boegeholz, Beatrice Latal, Maria Feldmann, Raimund Kottke, Cornelia Hagmann, Tanja Restin, Ruth Tuura O'Gorman, Andras Jakab, Michael Reinehr, Walter Knirsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cardiovascular Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2025.1556289/full
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