NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity
Conclusions: Our findings collectively elucidate that geniposide induces hepatotoxicity by triggering NLRP3 inflammasome signaling. Inhibition of the inflammasome presents a promising novel therapeutic target for mitigating geniposide-induced hepatotoxicity.
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/4112856 |
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| _version_ | 1823859596669747200 |
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| author | Yixuan Liu Baoyue Liu Mingzhu Shi Tianxiang Ye Huifang Li |
| author_facet | Yixuan Liu Baoyue Liu Mingzhu Shi Tianxiang Ye Huifang Li |
| author_sort | Yixuan Liu |
| collection | DOAJ |
| description | Conclusions: Our findings collectively elucidate that geniposide induces hepatotoxicity by triggering NLRP3 inflammasome signaling. Inhibition of the inflammasome presents a promising novel therapeutic target for mitigating geniposide-induced hepatotoxicity. |
| format | Article |
| id | doaj-art-25dbc9d478cf453b83737763816e24be |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-25dbc9d478cf453b83737763816e24be2025-02-11T00:00:02ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/4112856NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced HepatotoxicityYixuan Liu0Baoyue Liu1Mingzhu Shi2Tianxiang Ye3Huifang Li4School of Chinese Medicine and Food EngineeringSchool of Chinese Medicine and Food EngineeringSchool of Chinese Medicine and Food EngineeringSchool of Chinese Medicine and Food EngineeringSchool of Chinese Medicine and Food EngineeringConclusions: Our findings collectively elucidate that geniposide induces hepatotoxicity by triggering NLRP3 inflammasome signaling. Inhibition of the inflammasome presents a promising novel therapeutic target for mitigating geniposide-induced hepatotoxicity.http://dx.doi.org/10.1155/mi/4112856 |
| spellingShingle | Yixuan Liu Baoyue Liu Mingzhu Shi Tianxiang Ye Huifang Li NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity Mediators of Inflammation |
| title | NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity |
| title_full | NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity |
| title_fullStr | NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity |
| title_full_unstemmed | NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity |
| title_short | NLRP3 Inflammasome Activation Is Involved in Geniposide-Induced Hepatotoxicity |
| title_sort | nlrp3 inflammasome activation is involved in geniposide induced hepatotoxicity |
| url | http://dx.doi.org/10.1155/mi/4112856 |
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