Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications
Glioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer, poses significant therapeutic challenges. Despite our improved understanding of the cellular and molecular mechanisms underlying tumorigenesis and the evolution of GBM, targeted molecular therapies have failed...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Epigenetics and Epigenomics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/freae.2025.1519449/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849321297396367360 |
|---|---|
| author | Farzaneh Amirmahani Saurav Kumar Sree Deepthi Muthukrishnan |
| author_facet | Farzaneh Amirmahani Saurav Kumar Sree Deepthi Muthukrishnan |
| author_sort | Farzaneh Amirmahani |
| collection | DOAJ |
| description | Glioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer, poses significant therapeutic challenges. Despite our improved understanding of the cellular and molecular mechanisms underlying tumorigenesis and the evolution of GBM, targeted molecular therapies have failed to improve patient survival outcomes. The failure of standard treatments and targeted therapies is mainly attributed to the acquisition of phenotypic plasticity of tumor cells and GBM stem-like cells. Epigenetic modifications and their mediators have emerged as crucial regulators of phenotypic plasticity, influencing tumor heterogeneity, therapy resistance and disease progression. Here, we summarize and provide insights into epigenetic regulation of GBM plasticity and specifically, focus on the roles played by DNA- and histone modifiers and non-coding RNAs in driving phenotypic plasticity and resistance. We also delve into their dynamics in response to standard therapies and the challenges for targeting them to overcome phenotypic plasticity and resistance in GBM. |
| format | Article |
| id | doaj-art-25d088917c3049be96cbf7ea845559b4 |
| institution | Kabale University |
| issn | 2813-706X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Epigenetics and Epigenomics |
| spelling | doaj-art-25d088917c3049be96cbf7ea845559b42025-08-20T03:49:46ZengFrontiers Media S.A.Frontiers in Epigenetics and Epigenomics2813-706X2025-05-01310.3389/freae.2025.15194491519449Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implicationsFarzaneh AmirmahaniSaurav KumarSree Deepthi MuthukrishnanGlioblastoma (GBM), a highly aggressive and malignant form of primary adult brain cancer, poses significant therapeutic challenges. Despite our improved understanding of the cellular and molecular mechanisms underlying tumorigenesis and the evolution of GBM, targeted molecular therapies have failed to improve patient survival outcomes. The failure of standard treatments and targeted therapies is mainly attributed to the acquisition of phenotypic plasticity of tumor cells and GBM stem-like cells. Epigenetic modifications and their mediators have emerged as crucial regulators of phenotypic plasticity, influencing tumor heterogeneity, therapy resistance and disease progression. Here, we summarize and provide insights into epigenetic regulation of GBM plasticity and specifically, focus on the roles played by DNA- and histone modifiers and non-coding RNAs in driving phenotypic plasticity and resistance. We also delve into their dynamics in response to standard therapies and the challenges for targeting them to overcome phenotypic plasticity and resistance in GBM.https://www.frontiersin.org/articles/10.3389/freae.2025.1519449/fullGBMepigeneticDNA methylationhistone modificationsnon-coding RNAsGBM stem-like cells |
| spellingShingle | Farzaneh Amirmahani Saurav Kumar Sree Deepthi Muthukrishnan Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications Frontiers in Epigenetics and Epigenomics GBM epigenetic DNA methylation histone modifications non-coding RNAs GBM stem-like cells |
| title | Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications |
| title_full | Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications |
| title_fullStr | Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications |
| title_full_unstemmed | Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications |
| title_short | Epigenetic mechanisms of plasticity and resistance in glioblastoma: therapeutic targets and implications |
| title_sort | epigenetic mechanisms of plasticity and resistance in glioblastoma therapeutic targets and implications |
| topic | GBM epigenetic DNA methylation histone modifications non-coding RNAs GBM stem-like cells |
| url | https://www.frontiersin.org/articles/10.3389/freae.2025.1519449/full |
| work_keys_str_mv | AT farzanehamirmahani epigeneticmechanismsofplasticityandresistanceinglioblastomatherapeutictargetsandimplications AT sauravkumar epigeneticmechanismsofplasticityandresistanceinglioblastomatherapeutictargetsandimplications AT sreedeepthimuthukrishnan epigeneticmechanismsofplasticityandresistanceinglioblastomatherapeutictargetsandimplications |