Reduction of alternative polarization of macrophages by short-term activated hepatic stellate cell-derived small extracellular vesicles

Reduction of alternative polarization of macrophages by short-term activated hepatic stellate cell-derived small extracellular vesicles

Abstract Background Activated hepatic stellate cells (HSCs) induce alternative (M2) polarization of macrophages and contribute to the progression of fibrosis and hepatocellular carcinoma (HCC). However, the effects of small extracellular vesicles released by HSCs (HSC-sEVs) during activation remain...

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Main Authors:	Yufeng Sun, Min Zhao, Li Cheng, Xiaoqian He, Shiqi Shen, Jiaying Lv, Junyu Zhang, Qian Shao, Wenxuan Yin, Fengbo Zhao, Rui Sun, Peng Lu, Yuhua Ji, Xin Wei Wang, Juling Ji
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Series:	Journal of Experimental & Clinical Cancer Research
Online Access:	https://doi.org/10.1186/s13046-025-03380-0
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