A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans.

Apical extracellular matrices (aECMs) act as crucial barriers, and communicate with the epidermis to trigger protective responses following injury or infection. In Caenorhabditis elegans, the skin aECM, the cuticle, is produced by the epidermis and is decorated with periodic circumferential furrows....

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Bibliographic Details
Main Authors: Thomas Sonntag, Shizue Omi, Antonina Andreeva, Claire Valotteau, Jeanne Eichelbrenner, Andrew D Chisholm, Jordan D Ward, Nathalie Pujol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011593
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