Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model

Tumor-specific AAV delivery of interleukin-12 enhances antitumor immunity and safety in ovarian cancer xenograft mouse model

Interleukin-12 (IL-12) is a promising pro-inflammatory cytokine for cancer immunotherapy, but its toxicity and short half-life in serum limit its clinical application. Tumor-targeted delivery of IL-12 by fusion with either antibody or secretion by chimeric antigen receptor T (CAR-T) cells showed red...

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Bibliographic Details
Main Authors: Chuyuan Chen, Yongji Jiang, Chuan Feng, Qingyun Zhou, Xingrong Luo, Lili Cai, Lei Zhao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
cell specific AAV
interleukin-12
tumor microenvironment
solid tumor
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329925000712
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