Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway

Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway

Abstract Background Persistent controversies surround the treatment of Immunoglobulin A nephropathy (IgAN), necessitating the exploration of safer and more effective therapeutic agents. Tripterygium wilfordii, a traditional Chinese medicine, demonstrates promising benefits in reducing proteinuria an...

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Bibliographic Details
Main Authors: Yanping Wu, Ruman Chen, Danfang Deng, Wenjing Wu, Xiaoqin Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Nephrology
Subjects:
IgA nephropathy
Transglutaminase-2
High mobility group protein B1
Celastrol
Online Access:https://doi.org/10.1186/s12882-025-04139-7
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https://doi.org/10.1186/s12882-025-04139-7

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