A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA)

A Multifaceted Computational Approach to Identify PAD4 Inhibitors for the Treatment of Rheumatoid Arthritis (RA)

Background/Objectives: Neutrophil cells’ lysis forms the extracellular traps (NETs) to counter the foreign body during insults to the body. Peptidyl arginine deiminase (PAD) participates in this process and is then released into the extracellular fluid with the lysed cell components. In some disease...

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Main Authors: Mansour S. Alturki, Mohamed S. Gomaa, Nada Tawfeeq, Abdulaziz H. Al Khzem, Mohsina B. Shaik, Murtadha Alshaikh Jafar, Mohammad Alsamen, Hasan Al Nahab, Mohammad Al-Eid, Alhassan Almutawah, Thankhoe A. Rants’o, Khaled A. G. Ayil, Mohammed Almaghrabi
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Metabolites
Subjects:
PAD4
PAD IV
rheumatoid arthritis
PAD4 activity
PAD4 inhibitor
citrullination
Online Access:https://www.mdpi.com/2218-1989/15/3/156
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