Potential of Novel EPO Derivatives in Limb Ischemia
Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/213785 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563344359292928 |
|---|---|
| author | Dhiraj Joshi Janice Tsui Rebekah Yu Xu Shiwen Sadasivam Selvakumar David J. Abraham Daryll M. Baker |
| author_facet | Dhiraj Joshi Janice Tsui Rebekah Yu Xu Shiwen Sadasivam Selvakumar David J. Abraham Daryll M. Baker |
| author_sort | Dhiraj Joshi |
| collection | DOAJ |
| description | Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia. |
| format | Article |
| id | doaj-art-25827942427d4268bb33d6fb5b8cc237 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-25827942427d4268bb33d6fb5b8cc2372025-02-03T01:20:23ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/213785213785Potential of Novel EPO Derivatives in Limb IschemiaDhiraj Joshi0Janice Tsui1Rebekah Yu2Xu Shiwen3Sadasivam Selvakumar4David J. Abraham5Daryll M. Baker6Vascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKCentre for Rheumatology, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKCentre for Rheumatology, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKVascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UKErythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.http://dx.doi.org/10.1155/2012/213785 |
| spellingShingle | Dhiraj Joshi Janice Tsui Rebekah Yu Xu Shiwen Sadasivam Selvakumar David J. Abraham Daryll M. Baker Potential of Novel EPO Derivatives in Limb Ischemia Cardiology Research and Practice |
| title | Potential of Novel EPO Derivatives in Limb Ischemia |
| title_full | Potential of Novel EPO Derivatives in Limb Ischemia |
| title_fullStr | Potential of Novel EPO Derivatives in Limb Ischemia |
| title_full_unstemmed | Potential of Novel EPO Derivatives in Limb Ischemia |
| title_short | Potential of Novel EPO Derivatives in Limb Ischemia |
| title_sort | potential of novel epo derivatives in limb ischemia |
| url | http://dx.doi.org/10.1155/2012/213785 |
| work_keys_str_mv | AT dhirajjoshi potentialofnovelepoderivativesinlimbischemia AT janicetsui potentialofnovelepoderivativesinlimbischemia AT rebekahyu potentialofnovelepoderivativesinlimbischemia AT xushiwen potentialofnovelepoderivativesinlimbischemia AT sadasivamselvakumar potentialofnovelepoderivativesinlimbischemia AT davidjabraham potentialofnovelepoderivativesinlimbischemia AT daryllmbaker potentialofnovelepoderivativesinlimbischemia |