Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway

Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway

Background: Ezetimibe is used to treat cardiovascular disease as it blocks the sterol transporter Niemann-Pick C1-Like 1 (NPC1CL1) protein. However, recent evidence indicates that Ezetimibe inhibits several cancers indirectly by reducing circulating cholesterol or via specific signalling pathways. M...

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Bibliographic Details
Main Authors:	Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Biomedicines
Subjects:	p53 Mdm2 drug design drug development drug repurposing Ezetimibe
Online Access:	https://www.mdpi.com/2227-9059/13/1/195
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