Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations.

Quiescence modulates age-related changes in the functional capacity of highly proliferative canine lung mesenchymal stromal cell populations.

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The functional capacity of highly proliferative cell populations changes with age. Here, we report that the proliferative capacity of canine lung mesenchymal stromal cells (LMSCs) declines with increasing age of the donor. However, other functional changes such as reduced autophagy, reduced migratio...

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Main Authors: Nakesha Agyapong, Leslie Dominguez-Ortega, Brian Macdonough, Patrick Mulluso, Sagar Patel, Briti Prajapati, Brian Saville, Andrew Shapiro, Ethan Trim, Kara Battaglia, Jocelyn Herrera, Gianna Garifo-MacPartland, Dianne Newcomb, Latoya Okundaye, Heather Paglia, Julia Paxson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0319723
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https://doi.org/10.1371/journal.pone.0319723

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