Temporal trends of a cellular host response test for sepsis and a comparison with selected biomarkers of inflammation and infection

Temporal trends of a cellular host response test for sepsis and a comparison with selected biomarkers of inflammation and infection

Abstract Sepsis, a condition characterized by immune dysregulation, is the leading cause of in-hospital mortality and requires rapid treatment. Assessing immune dysregulation has been challenging. The IntelliSep Index (ISI), a novel biomarker which leverages microfluidic deformability cytometry to a...

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Main Authors: Matthew S. Berlinger, Matt Sorrells, Christopher B. Thomas, Tonya Jagneaux, James E. Walker, Jennifer Daigle, Heather Quiriarte, Youyoung Kim, Guillaume Spielmann, Debbie Robertson, Susan Park Ochsner, Gideon Avornu, Katherine Fenstermacher, Elijah James Kurien, Camille King, Adenine Cembellin-Kao, Chase Yonamine, Querino Maia, Maciej Obrebski, David N. Hager, Roya Sheybani, Henry T. K. Tse, Ajay M. Shah, Robert Scoggins, Hollis R. O’Neal, Richard Rothman
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
IntelliSep Index (ISI)
Sepsis diagnosis
Immune activation
Sepsis biomarkers
Organ dysfunction
Antimicrobial stewardship
Online Access:https://doi.org/10.1038/s41598-025-14860-w
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https://doi.org/10.1038/s41598-025-14860-w

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