Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials

Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials

Abstract Introduction Practice effects (PEs) on cognitive tests obscure decline, thereby delaying detection of mild cognitive impairment (MCI). Importantly, PEs may be present even when there are performance declines, if scores would have been even lower without prior test exposure. We assessed how...

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Main Authors: Mark Sanderson‐Cimino, Jeremy A. Elman, Xin M. Tu, Alden L. Gross, Matthew S. Panizzon, Daniel E. Gustavson, Mark W. Bondi, Emily C. Edmonds, Graham M.L. Eglit, Joel S. Eppig, Carol E. Franz, Amy J. Jak, Michael J. Lyons, Kelsey R. Thomas, McKenna E. Williams, William S. Kremen, Alzheimer's Disease Neuroimaging Initiative
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
clinical trials
early diagnosis
longitudinal aging
mild cognitive impairment
practice effects
Online Access:https://doi.org/10.1002/trc2.12228
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https://doi.org/10.1002/trc2.12228

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