Ocular immune privilege in action: The living eye imposes unique regulatory and anergic gene signatures on uveitogenic T cells

Summary: Despite ocular immune privilege, circulating retina-specific T cells can trigger autoimmune uveitis, yet intraocular bleeding—a relatively common event—rarely leads to disease. Using an in vivo immune privilege model, we previously reported that all naive retina-specific T cells entering th...

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Bibliographic Details
Main Authors: Zixuan Peng, Vijayaraj Nagarajan, Reiko Horai, Yingyos Jittayasothorn, Mary J. Mattapallil, Rachel R. Caspi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005510
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