Axillaridine A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via inhibition of RANKL-mediated RANK signaling pathways

Axillaridine A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via inhibition of RANKL-mediated RANK signaling pathways

Steroidal alkaloids are the main active components in many medicinal plants and exhibit diverse biological activities. Axillaridine A (AA) is a newly discovered steroidal alkaloid. However, whether AA could suppress osteoclastogenesis and alleviate ovariectomy-induced bone loss in mice remains unkno...

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Bibliographic Details
Main Authors: Jin Li, Jing Xu, Zhe Jiang, Meiyan Duan, Yingqi Yin, Zemin Xiang, Xuanjun Wang, Jun Sheng, Titi Liu, Huanhuan Xu
Format: Article
Language:English
Published: Tsinghua University Press 2025-06-01
Series:Food Science and Human Wellness
Subjects:
axillaridine a
osteoclastogenesis
rankl-rank
rank signaling pathways
bone loss
osteoporosis
Online Access:https://www.sciopen.com/article/10.26599/FSHW.2024.9250397
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https://www.sciopen.com/article/10.26599/FSHW.2024.9250397

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