Endothelial GNAQ p.R183Q mutation confers hemoporfin-mediated photodynamic therapy resistance and drives pathological angiogenesis via the angiopoietin-2/TIE2/PI3K/AKT pathway

Endothelial GNAQ p.R183Q mutation confers hemoporfin-mediated photodynamic therapy resistance and drives pathological angiogenesis via the angiopoietin-2/TIE2/PI3K/AKT pathway

Hemoporfin-mediated photodynamic therapy (HMME-PDT) has demonstrated significant advantages in the treatment of Port-wine stains (PWSs). However, the therapeutic efficacy of HMME-PDT remains suboptimal in a subset of patients. Somatic mosaic mutations in GNAQ (c.548G>A, p. R183Q) are frequent...

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Main Authors: Lu Liu, Linmei Wang, Jiaxin Luo, Jiayun Yu, Liang Xie, Yang Liu, Hong Xu, Fan Hu, Hanmin Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
port-wine stains
angiopoietin-2
photodynamic therapy
apoptosis
angiogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1622961/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1622961/full

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