Exploration of the chemical space of benzamide-based voltage-gated potassium channel Kv1.3 inhibitors

Exploration of the chemical space of benzamide-based voltage-gated potassium channel Kv1.3 inhibitors

The voltage-gated potassium channel Kv1.3 is a key regulator of T-cell activation and a validated therapeutic target for autoimmune and inflammatory diseases. In this study, a ligand-based design strategy was employed to expand a library of benzamide-derived Kv1.3 inhibitors. Starting from a previou...

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Bibliographic Details
Main Authors: Fois Marzia, Pelcar Špela, Nasburg Joshua A., Wulff Heike, Mašič Lucija Peterlin, Tomašič Tihomir
Format: Article
Language:English
Published: Sciendo 2025-06-01
Series:Acta Pharmaceutica
Subjects:
kv1.3
inhibitor
ion channel
ligand-based design
molecular modeling
Online Access:https://doi.org/10.2478/acph-2025-0019
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https://doi.org/10.2478/acph-2025-0019

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