HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis

HMGA2 interacts with KAT6A to regulate MMPs chromatin architecture and promote triple-negative breast cancer metastasis

BackgroundTriple-negative breast cancer (TNBC), the most lethal breast cancer subtype, demonstrates poor prognosis due to its high rates of metastasis, recurrence, and mortality. The metastatic potential in TNBC patients serves as a critical determinant of clinical outcomes. The high mobility group...

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Bibliographic Details
Main Authors: Lu Qiao, Zenghua Liang, Pengyi Ma, Shanshan Zhang, Cuiyun Sun, Wenjun Luo, Lin Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
triple-negative breast cancer
high mobility group AT-hook 2
matrix metalloproteinases
lysine acetyltransferase 6A
metastasis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590368/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1590368/full

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