PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

PI3K/AKT signaling and neuroprotection in ischemic stroke: molecular mechanisms and therapeutic perspectives

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic stroke. As a result, the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from researchers. This article reviews the pathological mechanisms and a...

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Bibliographic Details
Main Authors: Tianlong Liu, Xiaolin Li, Xiaowei Zhou, Wei Chen, Aidong Wen, Minna Liu, Yi Ding
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-10-01
Series:Neural Regeneration Research
Subjects:
apoptosis
autophagy
inflammation
ischemic stroke
neuroprotection
oxidative stress
pathogenesis
phosphatidylinositol 3-kinase
protein kinase b
therapeutics
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00568
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