A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways

A TRPV1 agonist from the transcriptome profiling of Dipsastraea rotumana inhibits neuroinflammation in vivo through the NF-κB and MAPK pathways

Neuroinflammation, defined as the inflammatory response in the brain or spinal cord, plays a pivotal role in multiple neurodegenerative conditions including Parkinson's and Alzheimer's diseases. Transient receptor potential cation channel subfamily V member 1 (TRPV1), widely expressed in m...

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Main Authors: Hanbin Chen, Nan Xu, Hiotong Kam, Chen Zhao, Qian Chen, Guangyi Fan, Shirley Weng In Siu, Clarence Tsun Ting Wong, Jian-Wen Qiu, Alex Kwok-Kuen Cheung, Ariane Teixeira, Gandhi Rádis‑Baptista, Pak Kin Wong, Shang Li, Guiyi Gong, Simon Ming-Yuen Lee
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Neuroinflammation
Kunitz-type peptides
TRPV1 agonist
NF-κB
MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002622
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