IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxia

Abstract Invasive C. albicans infections result in high mortality rates. While IL-1 is important to combat C. albicans infections, the underlying mechanisms remain unclear. Using global and conditional Il1r1 knockouts in mice, here we show that IL-1R signaling in non-hematopoietic cells in the kidne...

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Main Authors: Sofia Horn, Mareike Schmid, Ivan Berest, Federica Piattini, Jing Zhang, Katrien de Bock, Olivier Devuyst, Stellor Nlandu Khodo, Jan Kisielow, Manfred Kopf
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57797-4
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https://doi.org/10.1038/s41467-025-57797-4

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