Targeting YBX1‐m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma

Targeting YBX1‐m5C mediates RNF115 mRNA circularisation and translation to enhance vulnerability of ferroptosis in hepatocellular carcinoma

Abstract Background RNA 5‐methylcytosine (m5C) plays an important role in the progression of hepatocellular carcinoma (HCC). Dysregulation of ferroptosis is closely associated with HCC. However, the effect of the epigenetic mRNA m5C modification on ferroptosis in HCC remains unclear. Methods In this...

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Main Authors: Ouwen Li, Ke An, Han Wang, Xianbin Li, Yueqin Wang, Lan Huang, Yue Du, Nuo Qin, Jiasheng Dong, Jingyao Wei, Ranran Sun, Yong Shi, Yanjia Guo, Xiangyi Sun, Ying Yang, Yun‐Gui Yang, Quancheng Kan, Xin Tian
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Subjects:
5‐methylcytosine modification
ferroptosis
hepatocellular carcinoma
translational regulation
YBX1
Online Access:https://doi.org/10.1002/ctm2.70270
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https://doi.org/10.1002/ctm2.70270

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