A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.

<h4>Introduction</h4>Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H, R539W and R555C have been shown to decrease KCNQ1 interaction with PIP2. A previous study suggested that R539W i...

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Main Authors: Fabien C Coyan, Fayal Abderemane-Ali, Mohamed Yassine Amarouch, Julien Piron, Jérôme Mordel, Céline S Nicolas, Marja Steenman, Jean Mérot, Céline Marionneau, Annick Thomas, Robert Brasseur, Isabelle Baró, Gildas Loussouarn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093255&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093255&type=printable

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