B cells upregulate NMDARs, respond to extracellular glutamate, and express mature BDNF to protect the brain from ischemic injury

B cells upregulate NMDARs, respond to extracellular glutamate, and express mature BDNF to protect the brain from ischemic injury

Following stroke, B cells enter brain regions outside of the ischemic injury to mediate functional recovery. Although B cells produce neurotrophins that support remote plasticity, including brain-derived neurotrophic factor (BDNF), it remains unclear which signal(s) activate B cells in the absence o...

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Bibliographic Details
Main Authors: Vanessa O. Torres, Jadwiga Turchan-Cholewo, Mary K. Colson, Pavel Yanev, Daimen R.S. Britsch, Katherine M. Cotter, Annabel M. McAtee, Thomas A. Ujas, Domenico Mercurio, Xiangmei Kong, Erik J. Plautz, Chaitanya R. Joshi, Takeshi K. Matsui, Eiichiro Mori, Ambar Cajigas-Hernandez, Kielen Zuurbier, Steven Estus, Mark P. Goldberg, Nancy L. Monson, Ann M. Stowe
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neurobiology of Disease
Subjects:
Cerebral ischemia
B lymphocytes
GluN2A
GluN2B
Brain-derived neurotrophic factor
IL-10
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500035X
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