Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

BackgroundLecanemab, a monoclonal antibody targeting soluble amyloid-β protofibrils, has demonstrated efficacy in reducing amyloid burden in patients with mild cognitive impairment (MCI). However, its effects on brain structure, cerebral perfusion, gray matter microstructure and white matter microst...

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Main Authors: Toshiya Takahashi, Dinh Ha Duy Thuy, Shingo Takenaka, Sayaka Ono, Maya Fukui, Yasushi Okada, Tomohiko Asada, Kan Niimi, Kaku Kimura, Akio Ikeda, Ryosuke Takahashi, Riki Matsumoto, Hidenao Fukuyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
lecanemab
mild cognitive impairment (MCI)
longitudinal MRI
cerebral blood flow (CBF)
microstructure
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1651596/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1651596/full

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