Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement

Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement

Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that primarily affects the motor neurons, causing progressive muscle weakness and paralysis. While research has focused on understanding pathological mechanisms in the motor cortex and spinal cord, there is growin...

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Main Authors: Natalie Grima, Andrew N. Smith, Claire E. Shepherd, Lyndal Henden, Thiri Zaw, Luke Carroll, Dominic B. Rowe, Matthew C. Kiernan, Ian P. Blair, Kelly L. Williams
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis
TDP-43 pathology
RNA-seq
Transcriptome
Alternative splicing
Cryptic splicing
Online Access:https://doi.org/10.1186/s13024-025-00820-5
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https://doi.org/10.1186/s13024-025-00820-5

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