The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway

The inhibitory receptor LAG3 affects NK cell IFN-γ production through glycolysis and the PSAT1/STAT1/IFNG pathway

ABSTRACT Natural killer (NK) cells are integral to the innate immune system and crucial for antiviral defense. NK cell activation and functional state are suppressed by inhibitory receptors. Lymphocyte activation gene 3 (LAG3) is an important inhibitory receptor, but the associated signaling pathway...

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Main Authors: Hongchi Ge, Nan Guo, Yufei Liu, Bin Lang, Xiaowan Yin, Xiaowen Yu, Zining Zhang, Yajing Fu, Haibo Ding, Qinghai Hu, Xiaoxu Han, Wenqing Geng, Hong Shang, Yongjun Jiang
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
LAG3
HIV
NK
IFN-γ
glycolysis
STAT1
Online Access:https://journals.asm.org/doi/10.1128/mbio.00230-25
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https://journals.asm.org/doi/10.1128/mbio.00230-25

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