Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease

Human skeletal muscle mitochondrial pathways are impacted by a neuropathologic diagnosis of Alzheimer's disease

Alzheimer's disease (AD) is associated with reduced lean mass and impaired skeletal muscle mitochondrial and motor function. Although primary mitochondrial defects in AD may underlie these findings, molecular alterations in AD have not been thoroughly examined in human skeletal muscle. Here, we...

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Bibliographic Details
Main Authors: Chelsea N. Johnson, Mara R. Evans, Anneka E. Blankenship, Casey S. John, Michaella J. Rekowski, Michael P. Washburn, Andy Phan, Cynthia M. Gouvion, Mohammad Haeri, Russell H. Swerdlow, Paige C. Geiger, Jill K. Morris
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
APOE4
Skeletal muscle
Temporalis
Quadriceps
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125001329
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