Targeting TOP2A in Ovarian Cancer: Biological and Clinical Implications

Targeting TOP2A in Ovarian Cancer: Biological and Clinical Implications

The enzyme topoisomerase II alpha (TOP2A) plays a critical role in DNA replication and cell proliferation, making it a promising target for cancer therapy. In epithelial ovarian cancer (EOC), TOP2A overexpression is associated with poor prognosis and resistance to conventional treatments. This revie...

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Main Authors: Fulvio Borella, Stefano Fucina, Ylenia Seminara, Pietro Denti, Domenico Ferraioli, Luca Bertero, Niccolò Gallio, Jessica Cusato, Giorgio Valabrega, Alberto Revelli, Luca Marozio, Stefano Cosma
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Current Oncology
Subjects:
TOP2A
topoisomerase
ovarian cancer
anthracyclines
doxorubicin
etoposide
Online Access:https://www.mdpi.com/1718-7729/31/12/594
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